This handout book explains how to pull the correct levers to successfully connect health care and population health by understanding: the affordable care act and population health; ACO policy and population health; and HRSA perspective of the affordable care act and population health. It also provides details regarding hot-spotters: high-intensity interventions through examples such as: Southcentral Foundation Nuka System of Care; transforming health care by using a neighborhood empowerment approach; Austen BioInnovation Institute in Akron (ABIA); and improving care together with Camden Coalition of Health Providers. Then, it analyzes which of the following approaches could work best: Hennepin Health; Population Health Efforts Cambrifge Health Alliance; and Cattaraugus County Collaboration.